Influenza evolution within and between human hosts

Our study of influenza virus evolution in naturally infected people is out in eLife. In collaboration with Arnold Monto and Emily Martin (UM SPH), we sequenced virus populations from 200 infected individuals in the HIVE cohort. We found that positive selection is inefficient at the level of the individual host and that stochastic processes dominate the host-level evolution of influenza viruses. Here’s a profile of the work.

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