Our study of influenza virus evolution in naturally infected people is out in eLife. In collaboration with Arnold Monto and Emily Martin (UM SPH), we sequenced virus populations from 200 infected individuals in the HIVE cohort. We found that positive selection is inefficient at the level of the individual host and that stochastic processes dominate the host-level evolution of influenza viruses. Here’s a profile of the work.
JT successfully defended his thesis on the within and between host evolution of influenza virus. He will stick around for a couple of months to wrap up some ongoing projects, then head to Edinburgh for a postdoctoral fellowship with Andrew Rambaut.
JT McCrone publishes a review of transmission bottlenecks in Current Opinion in Virology
Danny Lyons publishes a paper in Molecular Biology and Evolution showing that tranversion mutations are more damaging than transitions in HIV and influenza virus.
Adam receives a 5 year grant from the Investigators in the Pathogenesis of Infectious Disease Program. This generous and flexible support will allow us to explore new projects related to viral transmission and the evolution of virulence. Press Release